Tra le centinaia di covers oltre a quella di Louis Armstrong, che diede alla canzone una fama duratura con la sua registrazione del 1928, ci stanno:
The Hokum Boys - Gambler's Blues (1929)
Artie Shaw and His Orchestra, with Hot Lips Page providing vocals (1941)
Josh White (1944)
Turk Murphy (1951)
Kid Ory's Creole Jazz Band - Kid Ory's Creole Jazz Band 1953 (1953)
Johnny Duncan - Johnny Duncan's Tennessee Song Bag (1958)
Snooks Eaglin – New Orleans Street Singer (Folkways, 1959)
Dave Van Ronk - "Gambler's Blues", on Dave Van Ronk Sings Ballads, Blues, and a Spiritual (1959)
Lou Rawls – Black and Blue (1963)
Colette Magny - "St. James Infirmary Blues" (1964)
The Standells – Try It (1967)
Joe Dassin – St. James Infirmary Blues (1967)
Jerry Reed - Jerry Reed Explores Country Guitar (1969)
Joe Cocker – Joe Cocker (1972)
Geordie - "Goin' Down", on Don't Be Fooled by the Name (1974)
Lily Tomlin - Saturday Night Live (1975)
Canadian Brass – Basin Street (1987)
Doc Watson and Richard Watson – Third Generation Blues (1999)
Toshiyuki Honda – Metropolis original motion picture soundtrack (2001)
Isobel Campbell and Mark Lanegan (2005)
The Devil Makes Three – A Little Bit Faster and a Little Bit Worse (under the title St James) (2006)
Arlo Guthrie with the University of Kentucky Symphony Orchestra – In Times Like These (2007)
Rising Appalachia – The Sails of Self (2010)
Hugh Laurie – Let Them Talk (2011)
Rickie Lee Jones – The Devil You Know (2012)
Jon Batiste and Stay Human, Social Music; (2013)
Dalice Marie – Twenty Eight (2016)
Yo-Yo Ma's Silkroad Ensemble with Rhiannon Giddens – Sing Me Home (2016)
Jon Batiste – Hollywood Africans (2018)
The Bridge City Sinners - Bridge City Sinners (2016)
Liquor Beats Winter - Lost In The Sauce (2018)
ehm, e gnente!
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